Discussions

Polypeptide conjugation-based half-life extension is an innovative approach in the realm of drug development, aimed at prolonging the activity duration of therapeutic agents. By conjugating polypeptides to drugs, researchers can enhance the molecules’ stability and reduce their clearance from the body. This technique involves attaching biodegradable polypeptides that increase the drug’s size and mask sites susceptible to enzymatic degradation. Polypeptide conjugation-based half-life extension is particularly effective for biologics, such as proteins and antibodies, where it helps in sustaining therapeutic levels with less frequent dosing. This method not only optimizes the therapeutic efficacy but also improves patient convenience and adherence to treatment regimens.